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| Catalog Number | CI-HS-0007 |
| Product Name | Carbomers |
| CAS | 9007-20-9 |
| Structure |  |
| Description | Carbomers are a group of synthetic polymers derived from acrylic acid. They are commonly used as thickening agents and emulsifiers in various personal care and cosmetic products such as lotions, creams, gels, and hair styling products. Carbomers provide a smooth and consistent texture to the product, prevent separation of ingredients, and enhance the stability of the formula. They can also be used to adjust the viscosity and flow properties of the product. Some potential benefits of using carbomers in personal care products include improved hydration, better absorption of active ingredients, and increased spreadability of the product on the skin or hair. |
| Appearance | white, fluffy, powdery or granular substances |
| Application | 1. Carbomers are commonly used in the pharmaceutical industry as thickeners, suspending agents, and stabilizers for lotions, ointments, and gels. 2. In personal care products, carbomers can be used as emulsifiers, thickeners, and stabilizers in shampoos, conditioners, and lotions. 3. They are sometimes used in the food industry as gelling agents and stabilizers in products such as salad dressings and sauces. 4. Carbomers can also be used in agriculture to improve water retention in soils and enhance the effectiveness of fertilizers. |
| Features And Benefits | 1. Provides viscosity control 2. Enhances product stability 3. Imparts smooth and silky texture 4. Improves product spreadability 5. Increases the shelf life of the product 6. Acts as a suspending agent for insoluble ingredients 7. Enables the formation of clear gels 8. Forms a protective film on the skin for improved hydration. |
Hayati, Farzad, et al. Journal of Dermatological Treatment, 2018, 29(6), 593-599.
The purpose was to investigate the effect of carbomer 940 hydrogel in skin burn wounds especially with respect to the stasis zone. It reported that carbomer 940 hydrogel is a biomaterial that was safe and increased tissue perfusion and decreased the necrotic tissue in burn injuries.
· Preparation of Hydrogel
The study utilized carbomer 940 polymer. A 1% concentration of carbomer 940 was combined with Krebs-Henseleit buffer solution at pH 7.4. Sodium hydroxide was then added to neutralize the pH and ensure clarity of the gels. After incorporating the total solid content, the gels were allowed to swell at room temperature.
· Evaluation Methods and Results
To determine the cytotoxicity of carbomer 940, fibroblast cells were employed. Wound healing progress was tracked using laser Doppler flowmetry and histopathological assessments. Results showed an increase in skin blood perfusion in the stasis zone at 24 hours post-burn in the experimental group compared to the control group (p < .05). Histological examination revealed a greater presence of epithelial tissue in the stasis zone of the experimental group, alongside viable sebaceous glands and hair follicles at day 3. Additionally, at day 21, there was a significantly higher extent of collagen deposition and fibroplasia in the ischemic areas of the experimental group relative to the control group.
Đekić, Ljiljana, et al. Pharmaceutics, 2024, 16(5), 628.
The structure of a cross-linked carbomer hydrogel with microencapsulated α-tocopherol was created and the effects of the microcapsule wall structure on the carrier system, the ability to be used with high water content carriers as topical carriers, and the release of α-tocopherol were studied.
· Preparation of α-tocopherol microcapsules
Aldehyde-free -tocopherol microcapsules without crosslinkers were produced by complex coacervation and spray drying of low molecular weight chitosan (LMWC) and sodium lauryl ether sulfate (SLES) as encapsulants. There were two cross-linker-free microcapsules with -tocopherol prepared from LMWC/SLES coacervates (mass ratio 2:1 and 1:1, respectively).
· Preparation of microencapsulated α-tocopherol hydrogel
The blank hydrogel was created by slowly mixing carbomer powder (0.5% w/w) into purified water while using the IKA RW 20 digital propeller laboratory mixer at a rate of 300 rpm. Added propylene glycol (10% w/w) and isopropyl alcohol (25% w/w) to the carbomer solution, and stirred at the same rate. The stirring speed was then raised to 400 rpm and neutralisation was performed by addition of triethanolamine (0.5% w/w) in 10% aqueous solution.
Each hydrogel that contained microencapsulated α-tocopherol was prepared by mixing the necessary amount of microcapsules into a specific quantity of the blank carbomer hydrogel, stirring at 300 rpm until a uniform semisolid was formed. The microcapsule concentration in each hydrogel was set at 5% w/w, with the remaining 95% constituting the hydrogel vehicle. The hydrogels were promptly filled into aluminum tubes after preparation to shield them from light and prevent evaporation during storage.
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