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| Catalog Number | CI-GU-0123 |
| Product Name | Beta-Sitosterol |
| CAS | 83-46-5 |
| Structure |  |
| Synonyms | Stigmast-5-en-3-beta-ol;Stigmast-5-en-3-ol, (3beta)- |
| IUPAC Name | (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| Molecular Weight | 414.7 g/mol |
| Molecular Formula | C29H50O |
| InChI | InChI=1S/C29H50O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h10,19-21,23-27,30H,7-9,11-18H2,1-6H3/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1 |
| InChI Key | KZJWDPNRJALLNS-VJSFXXLFSA-N |
| Melting Point | 136-140 °C |
| Purity | 95% |
| Density | 0.954 g/mL |
| Appearance | Solid |
| Highest Usage In Residency Products | 0.01 |
| Isomeric SMILES | CC[C@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C |
Beta-Sitosterol, a phytosterol with a chemical structure similar to cholesterol, is derived from various plants and holds significant value in both medical and skincare applications. It is extensively utilized in the management of hypercholesterolemia and diabetes due to its ability to act as a cholesterol agonist. In skincare formulations, Beta-Sitosterol is prized for its extensive benefits, including anti-aging, immunomodulatory, antimicrobial, anti-inflammatory, wound healing, and antioxidant properties. This ingredient, available as a food-grade (E499) waxy powder, is safe for use and offers formulators advantages like emulsion stabilization, fragrance fixation, and masking, along with superior skin conditioning effects. Its lipid origin aids in enhancing barrier function, promoting cell renewal, and providing protection against free radicals and oxidative stress. As a botanical alternative to cholesterol, Beta-Sitosterol is ideal for vegan-focused skincare products, delivering similar consistency and functionality. It stimulates skin fibroblasts and keratinocytes, fostering hyaluronic acid production and enhancing barrier performance while promoting the synthesis of proteins such as loricrin, filaggrin, and involucrin. This leads to improved moisture retention, natural moisturizing factors generation, and increased skin elasticity and smoothness. Emphasized in traditional Chinese medicine for its soothing properties, Beta-Sitosterol effectively addresses skin issues like atopic dermatitis, accelerates wound healing, and enhances skin recovery and renewal while offering protection from bacterial infections. It serves as a natural remedy that enriches skincare formulations, contributing to a healthier, more radiant complexion.
What is Beta-Sitosterol, and what are its primary uses?
Beta-Sitosterol is a phytosterol produced by various plants with a chemical structure similar to cholesterol. It is primarily used to treat hypercholesterolemia (high cholesterol levels) and manage diabetes. Additionally, it is an effective ingredient in skincare products due to its numerous beneficial effects, including anti-aging, immunomodulatory, antimicrobial, anti-inflammatory, and antioxidant actions.
How does Beta-Sitosterol benefit skincare formulations?
Beta-Sitosterol enhances skincare products by improving barrier function and promoting cell renewal, protection from free radicals, and oxidative stress. It aids in moisture retention and generates natural moisturizing factors (NMFs), contributing to improved skin elasticity, smoothness, and a youthful appearance. It also stimulates skin fibroblasts and keratinocytes and boosts the synthesis of essential skin proteins like loricrin, filaggrin, and involucrin.
Is Beta-Sitosterol safe for use in formulations, and what properties make it valuable for formulators?
Yes, Beta-Sitosterol is considered a safe and food-grade ingredient (E499) with beneficial properties for formulators. It is known for stabilizing emulsions, fixing fragrances, and masking undesired scents, all while delivering excellent skin conditioning effects. Its natural origin makes it an ideal choice for vegan-oriented products, providing similar consistency and functions as cholesterol.
Can Beta-Sitosterol be used in vegan skincare products?
Absolutely, Beta-Sitosterol is a perfect botanical alternative to cholesterol, offering the same consistency and functionality. It is suitable for vegan skincare formulations, making it a valuable ingredient for those seeking plant-based skincare solutions.
What are some traditional uses of plants containing Beta-Sitosterol?
Historically, plants containing Beta-Sitosterol have been used in Chinese medicine for their soothing effects on irritated skin and efficacy in treating conditions like atopic dermatitis. A natural remedy, Beta-Sitosterol expedites wound healing and skin recovery while safeguarding against bacterial infection, promoting a healthy, fresh, and glowing appearance.
How does Beta-Sitosterol contribute to anti-aging in skincare?
Beta-Sitosterol's anti-aging effects in skincare stem from its ability to enhance skin elasticity and smoothness by promoting the production of hyaluronic acid and essential skin proteins, as well as inhibiting oxidative stress. This combination of actions helps maintain a youthful and radiant skin appearance.
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