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| Catalog Number | CI-FC-0067 |
| Product Name | Arbutin |
| CAS | 497-76-7 |
| Structure |  |
| Synonyms | 4-Hydroxyphenyl-beta-d-glucopyranosid |
| IUPAC Name | (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol |
| Molecular Weight | 272.25 g/mol |
| Molecular Formula | C12H16O7 |
| InChI | InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1 |
| InChI Key | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
| Boiling Point | 375.31 °C |
| Melting Point | 195-198 °C |
| Density | 1.36 g/mL |
| Appearance | White solid |
| Isomeric SMILES | C1=CC(=CC=C1O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O |
Arbutin is a hydroquinone derivative glucoside frequently used in advanced skincare and pharmaceutical applications for its effective skin-whitening properties. By inhibiting tyrosinase activity, a key enzyme in melanin formation, Arbutin prevents hyperpigmentation and is particularly beneficial in treating conditions such as melasma, liver spots, and freckles. Originally extracted from the bearberry plant, it is now primarily synthesized using hydroquinone and glucose. Arbutin's ability to block melanin production without affecting cell proliferation makes it an essential ingredient in products designed for sunburn treatment and skin discoloration prevention. It is also incorporated in sun care and after-sun products for its efficacy in lightening skin and minimizing freckles, typically in concentrations ranging from 0.5% to 3.0%.
What is Arbutin and where is it derived from?
Arbutin is a white powder and a hydroquinone derivative glucoside found in various plants. It was initially extracted from the leaves of bearberry, which belongs to the Ericaceae family. However, most Arbutin used today is synthesized from hydroquinone and glucose.
How does Arbutin work to inhibit melanin formation?
Arbutin effectively prevents melanin formation by blocking the activity of tyrosinase, the key enzyme responsible for melanin production. It combines directly with tyrosinase and aids in the decomposition and excretion of melanin, thus prohibiting hyperpigmentation without affecting cell proliferation.
What are the common uses of Arbutin in skincare?
Arbutin is widely incorporated in skincare applications as a skin-whitening agent. It helps prevent liver spots and freckles, treat sunburn, and control melanin production. Arbutin is utilized in advanced cosmetics, skin-brightening products, and pharmaceuticals for the treatment of melasma and discoloration. Additionally, it is used in sun care and after-sun products to lighten skin and prevent hyperpigmentation.
What are the recommended concentrations of Arbutin in skincare products?
Arbutin is typically used in concentrations ranging from 0.5% to 3.0% in skincare formulations. These concentrations are considered effective for skin-brightening and pigmentation control.
Is Arbutin suitable for all skin types, and are there any known side effects?
Arbutin is generally considered suitable for all skin types due to its effectiveness and gentle action in inhibiting melanin production without affecting cell proliferation. However, as with any skincare ingredient, individual skin reactions may vary, and it is advisable to perform a patch test before using products containing Arbutin.
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