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| Catalog Number | CI-BP-0164 |
| Product Name | Acetyl tetrapeptide-3 |
| CAS | 827306-88-7 |
| Structure |  |
| Synonyms | N2-Acetyl-L-lysylglycyl-L-histidyl-L-lysinamide |
| IUPAC Name | (2S)-2-[[(2S)-2-[[2-[[(2S)-2-acetamido-6-aminohexanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanamide |
| Molecular Weight | 509.6 g/mol |
| Molecular Formula | C22H39N9O5 |
| InChI | InChI=1S/C22H39N9O5/c1-14(32)29-17(7-3-5-9-24)21(35)27-12-19(33)30-18(10-15-11-26-13-28-15)22(36)31-16(20(25)34)6-2-4-8-23/h11,13,16-18H,2-10,12,23-24H2,1H3,(H2,25,34)(H,26,28)(H,27,35)(H,29,32)(H,30,33)(H,31,36)/t16-,17-,18-/m0/s1 |
| InChI Key | RRJOMESUBQAYOA-BZSNNMDCSA-N |
| Boiling Point | 1075.4±65.0 °C |
| Density | 1.25 g/mL |
| Isomeric SMILES | CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)N |
| pKa | 13.35±0.46 |
Acetyl tetrapeptide-3, also recognized under the trade name Folixyl®, is a biomimetic peptide crafted from a specific growth factor with the sequence Ac-Lys-Gly-His-Lys-NH2 (KGHK). It has been strategically developed to address the symptoms of hair loss and encourage hair growth. By promoting the synthesis of extracellular matrix proteins such as Collagen I and III and laminin, Acetyl tetrapeptide-3 assists in renewing dermal papilla cells, countering the stiffening of the hair follicle sheath-a significant contributor to hair loss. Clinical tests on human hair follicles indicate that this peptide effectively stimulates hair growth. Furthermore, when compared to Minoxidil, a well-known hair growth treatment, Folixyl® demonstrated superior results in the percentage of hair growth observed after just seven days of application.
What is Acetyl tetrapeptide-3 and how does it work?
Acetyl tetrapeptide-3 is a biomimetic peptide derived from a growth factor. It is designed to combat hair loss and promote hair growth. It operates by stimulating the synthesis of follicle extracellular matrix proteins, such as Collagen I and III and laminin, thereby aiding in the renewal of dermal papilla cells and counteracting the hardening of the hair follicle sheath, which is a contributing factor to hair loss.
How effective is Acetyl tetrapeptide-3 compared to other hair growth treatments?
Studies conducted on human hair follicles have demonstrated that Acetyl tetrapeptide-3 effectively stimulates hair growth. When compared to Minoxidil, a widely used treatment for hair growth, Acetyl tetrapeptide-3 showed superior results in terms of the percentage of hair growth within just 7 days of treatment.
What are the benefits of using Acetyl tetrapeptide-3 in hair care products?
The primary benefits of using Acetyl tetrapeptide-3 in hair care products include its ability to enhance the synthesis of essential follicle extracellular matrix proteins, which are crucial for hair health and growth. This action supports the renewal of dermal papilla cells and helps prevent hair follicle sheath stiffening, thus contributing to healthier hair growth and the reduction of hair loss.
Can Acetyl tetrapeptide-3 be used by anyone experiencing hair loss?
While Acetyl tetrapeptide-3 is generally considered safe for use, it is advisable for individuals experiencing hair loss to consult with a healthcare professional or dermatologist to determine the most suitable treatment plan for their specific condition and to rule out any underlying health issues that may need to be addressed.
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