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| Catalog Number | CI-BP-0088 |
| Product Name | Acetyl pentapeptide-1 |
| CAS | 97530-32-0 |
| Structure |  |
| Synonyms | N2-acetyl-L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine |
| IUPAC Name | (3S)-3-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-6-aminohexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid |
| Molecular Weight | 721.81 g/mol |
| Molecular Formula | C32H51N9O10 |
| InChI | InChI=1S/C32H51N9O10/c1-17(2)26(30(49)40-24(31(50)51)15-19-9-11-20(43)12-10-19)41-29(48)23(16-25(44)45)39-28(47)22(7-4-5-13-33)38-27(46)21(37-18(3)42)8-6-14-36-32(34)35/h9-12,17,21-24,26,43H,4-8,13-16,33H2,1-3H3,(H,37,42)(H,38,46)(H,39,47)(H,40,49)(H,41,48)(H,44,45)(H,50,51)(H4,34,35,36)/t21-,22-,23-,24-,26-/m0/s1 |
| InChI Key | JGWAYIPLKPVOJZ-LENLALOCSA-N |
| Purity | 0.95 |
| Density | 1.42 g/mL |
| Appearance | White powder |
| Storage | -15~-20 °C |
| Isomeric SMILES | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C |
| pKa | 3.07±0.10 |
| Safety | No heavy metals, no skin and eye irritation |
Acetyl pentapeptide-1, known for its sequence Ac-Arg-Lys-Asp-Val-Tyr-OH, is an acetylated derivative of the Thymopoietin peptide, which is recognized for its ability to mimic immunomodulatory protein actions. This peptide offers multifaceted benefits in skincare, primarily by mitigating skin irritation and enhancing sensitive skin's resilience against infections. It functions by suppressing interleukins, notably IL-8, which in turn reduces the release of metalloproteinases such as MMP-9, thereby protecting against the breakdown of critical skin structural proteins like collagen and elastin. This prevention of collagen type IV degradation, an essential component of basement membranes, contributes to maintaining the skin's structural integrity. Thus, when incorporated into skincare products, Acetyl pentapeptide-1 serves as a versatile agent that not only soothes and protects the skin but also supports a firmer and more youthful complexion.
What is Acetyl Pentapeptide-1 and how does it benefit the skin?
Acetyl Pentapeptide-1, also known as Acetyl sh-Pentapeptide-1, is a stable derivative of sh-Pentapeptide-1, which mirrors the actions of a Thymopoietin peptide. It is designed to fight skin irritation, soothe sensitive skin, and enhance the skin's natural defense against infections. By suppressing certain signaling molecules, it helps reduce inflammation and prevent the breakdown of key structural proteins like collagen and elastin, promoting a firmer and more youthful skin appearance.
How does Acetyl Pentapeptide-1 work on a molecular level to improve skin health?
Acetyl Pentapeptide-1 works by suppressing interleukins, particularly IL-8, which are involved in the body's inflammatory response. This suppression leads to a decrease in the activity of metalloproteinases (MMPs), specifically MMP-9, which are enzymes responsible for degrading structural proteins such as collagen and elastin. By reducing the activity of these enzymes, Acetyl Pentapeptide-1 helps maintain the integrity of the skin's structure and appearance.
In what types of skincare products can Acetyl Pentapeptide-1 be found?
Acetyl Pentapeptide-1 is commonly incorporated into various skincare applications due to its multifunctional properties. It can be found in moisturizers, serums, creams, and other formulations aimed at soothing irritated skin, preventing structural protein breakdown, and providing a firmer, calmer, and more youthful skin appearance.
What specific skin concerns can Acetyl Pentapeptide-1 address?
Acetyl Pentapeptide-1 is particularly effective in addressing skin irritation and sensitivity. It also supports the skin's defense mechanisms against infections and environmental stressors. Additionally, by preventing the breakdown of collagen and elastin, it helps combat signs of aging, such as loss of firmness and elasticity, resulting in a smoother and more youthful complexion.
Is Acetyl Pentapeptide-1 suitable for all skin types?
Yes, Acetyl Pentapeptide-1 is suitable for all skin types, including sensitive skin. Its soothing and protective properties make it an ideal ingredient for individuals looking to strengthen their skin barrier, reduce irritation, and improve the overall health and appearance of their skin. However, as with any skincare product, it is always advisable to perform a patch test before incorporating it into your routine to ensure compatibility and avoid any potential allergic reactions.
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