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Acetyl hexapeptide-1

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Catalog Number	CI-BP-0086
Product Name	Acetyl hexapeptide-1
CAS	448944-47-6
Structure
Synonyms	N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide
IUPAC Name	(2S)-2-acetamido-N-[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]hexanamide
Molecular Weight	870.01 g/mol
Molecular Formula	C43H59N13O7
InChI	InChI=1S/C43H59N13O7/c1-4-5-15-32(52-26(3)57)39(60)51-25(2)38(59)55-36(21-29-23-47-24-50-29)42(63)56-35(19-27-12-7-6-8-13-27)41(62)53-33(17-11-18-48-43(45)46)40(61)54-34(37(44)58)20-28-22-49-31-16-10-9-14-30(28)31/h6-10,12-14,16,22-25,32-36,49H,4-5,11,15,17-21H2,1-3H3,(H2,44,58)(H,47,50)(H,51,60)(H,52,57)(H,53,62)(H,54,61)(H,55,59)(H,56,63)(H4,45,46,48)/t25-,32-,33-,34-,35+,36-/m0/s1
InChI Key	WPIQUSRULDNCKM-IFSWANACSA-N
Purity	0.95
Density	1.39 g/mL
Appearance	White powder
Storage	-15~-20 °C
Isomeric SMILES	CCCC[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N)NC(=O)C
pKa	13.36±0.46
Safety	No heavy metals, no skin and eye irritation

Product Overview

Acetyl Hexapeptide-1, a sophisticated biomimetic peptide developed by Unipex, is specifically designed to address the natural process of hair graying by promoting melanin production. This peptide, derived from alpha-MSH, plays a crucial role in stimulating melanin synthesis within melanocytes and facilitating the transfer of melanin to keratinocytes, thereby contributing to the restoration of hair's natural color. Extensive ex vivo experiments have demonstrated the efficacy of Acetyl Hexapeptide-1 in reducing the presence of white and low-pigmented cells while increasing the number of moderately and highly pigmented cells in hair follicles. Additionally, Acetyl Hexapeptide-1 is an active component in MelinOIL™, a formulation that enhances skin preparedness for sun exposure and provides protection against UV-induced photoaging.

Custom Q&A

What is Acetyl Hexapeptide-1 and how does it work in combating hair graying?

Acetyl Hexapeptide-1 is a biomimetic peptide derived from alpha-MSH, designed to counteract hair graying. It stimulates melanin synthesis by melanocytes and encourages the transfer of melanin to keratinocytes, which are crucial processes for maintaining hair color. By enhancing these processes, Acetyl Hexapeptide-1 helps to increase the number of moderately and highly-pigmented cells in hair bulbs, thus reducing the appearance of gray hair.

How effective is Acetyl Hexapeptide-1 in reversing gray hair?

Acetyl Hexapeptide-1 has shown outstanding results in ex vivo experiments on hair. It effectively decreases the number of white and low-pigmented cells and increases the number of moderate and highly-pigmented cells in hair bulbs. This indicates a significant potential for reversing gray hair and maintaining darker, more lustrous hair color.

Can Acetyl Hexapeptide-1 be used for purposes other than combating gray hair?

Yes, Acetyl Hexapeptide-1 is also incorporated into a peptide-based formula that prepares skin for sun exposure and provides protection from UV-induced photoaging. This makes it versatile for both hair and skincare applications.

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