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Catalog Number | CI-BP-0017 |
Product Name | Acetyl decapeptide-3 / Decapeptide-4 |
CAS | 935288-50-9 |
Structure | |
Synonyms | L-Tyrosinamide, N-acetyl-L-tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-threonyl-L-seryl-L-tryptophyl- |
IUPAC Name | (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-6-amino-N-[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]hexanamide |
Molecular Weight | 1450.6 g/mol |
Molecular Formula | C68H95N19O17 |
InChI | InChI=1S/C68H95N19O17/c1-36(90)56(66(104)86-55(35-89)65(103)84-53(32-41-33-77-46-10-4-3-9-45(41)46)62(100)82-50(57(70)95)29-38-14-20-42(92)21-15-38)87-63(101)52(31-40-18-24-44(94)25-19-40)83-59(97)47(11-5-6-26-69)79-58(96)48(12-7-27-75-67(71)72)81-64(102)54(34-88)85-60(98)49(13-8-28-76-68(73)74)80-61(99)51(78-37(2)91)30-39-16-22-43(93)23-17-39/h3-4,9-10,14-25,33,36,47-56,77,88-90,92-94H,5-8,11-13,26-32,34-35,69H2,1-2H3,(H2,70,95)(H,78,91)(H,79,96)(H,80,99)(H,81,102)(H,82,100)(H,83,97)(H,84,103)(H,85,98)(H,86,104)(H,87,101)(H4,71,72,75)(H4,73,74,76)/t36-,47+,48+,49+,50+,51+,52+,53+,54+,55+,56+/m1/s1 |
InChI Key | CGPSWQBETUSORI-MTUNXJOQSA-N |
Density | 1.49 g/mL |
Isomeric SMILES | C[C@H]([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)C)O |
pKa | 9.82±0.15 |
Acetyl decapeptide-3, also known as CG-Rejuline, is a synthetic peptide that emulates a portion of the basic Fibroblast Growth Factor (bFGF) protein, known for its crucial role in skin development, wound healing, and regeneration. This peptide actively promotes the proliferation and growth of fibroblasts, endothelial cells, and keratinocytes while offering protection against apoptosis. Beyond stimulating skin cell renewal, Acetyl decapeptide-3 enhances the expression of extracellular matrix proteins like collagen, fibronectin, and laminin, thereby reducing the visibility of fine lines and wrinkles and improving skin elasticity and firmness. Clinical evaluations demonstrate that Acetyl decapeptide-3 exhibits greater stability and extended effectiveness compared to native bFGF. Additionally, CG-Rejuline supports hair growth by fortifying follicles and encouraging new cell development.
What is Acetyl Decapeptide-3 and how does it work?
Acetyl Decapeptide-3, also known under the trade name CG-Rejuline, is a synthetic peptide that mimics a sequence of the Basic Fibroblast Growth Factor (bFGF) protein. Its primary function is to replicate and enhance the actions of bFGF in promoting skin development, wound healing, and regeneration. This peptide functions by boosting the growth and proliferation of fibroblasts, endothelial cells, and keratinocytes. Additionally, it protects these cells from apoptosis, contributing to a healthier skin environment.
What are the benefits of using Acetyl Decapeptide-3 in skincare?
The use of Acetyl Decapeptide-3 in skincare offers several benefits, including increased skin cell proliferation and renewal. It enhances the expression levels of extracellular matrix proteins such as collagen, fibronectin, and laminin, which are critical for maintaining skin firmness and elasticity. This results in the reduction of fine lines and wrinkles, leading to a more youthful, supple appearance. Moreover, Acetyl Decapeptide-3 has shown more stability and a prolonged action compared to the native bFGF protein during clinical tests.
Can Acetyl Decapeptide-3 be used for hair care?
Yes, Acetyl Decapeptide-3, or CG-Rejuline, is also beneficial for hair care. It promotes hair growth by strengthening hair follicles and boosting new cell development. This results in healthier, stronger hair, making it a valuable ingredient in products aimed at enhancing hair vitality and reducing hair loss.
How does Acetyl Decapeptide-3 compare to native bFGF in terms of performance?
In clinical tests, Acetyl Decapeptide-3 exhibited greater stability and a longer duration of activity compared to native bFGF. This enhanced stability allows for more sustained benefits, making it an effective option for long-term skin and hair care applications focused on anti-aging and regenerative results.